Kantar Health Blog

  • Biomarkers in Breast Cancer: More Than Just HER2

    by Stephanie Hawthorne | Apr 8, 2013
    Stephanie Hawthorne
    Oncology Conference Insight - AACR 2013 --- On Sunday at the American Association for Cancer Research (AACR) 2013 annual meeting, Jose Baselga presented new data from the Phase III EMILIA trial (Abstract LB-63) that suggested a relationship between tumor biomarkers and efficacy of Kadcyla® (TDM-1, ado-trastuzumab emtansine; Roche/Genentech). Kadcyla is a novel antibody-drug conjugate that comprises a potent microtubule polymerization inhibitor conjugated to the Herceptin® (trastuzumab; Roche / Genentech) monoclonal antibody via a highly stable linker.
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  • Stephanie Hawthorne
    Oncology Conference Insight - ASCO GI 2013 With recent news being so heavily centered on targeted agents, it seems as though people often forget about the value that chemotherapy has provided over the years and, more importantly, that there is still room for improvement in these older regimens to generate significantly better outcomes for patients. Celgene was looking to take advantage of this sentiment when the company acquired Abraxis BioScience and their leading drug candidate, Abraxane®, an injectable suspension of nanoparticle albumin bound (nab)-paclitaxel.
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  • Stephanie Hawthorne
    Oncology Conference Insight Blogs - ASH 2012 Pomalidomide is a next-generation immunomodulatory agent in development for relapsed/refractory multiple myeloma, designed to follow in the footsteps of its siblings, Revlimid (lenalidomide, Celgene) and Thalomid (thalidomide, Celgene). In spite of the increased competition, pomalidomide will be eagerly included into the drug armamentarium for myeloma patients.
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  • Stephanie Hawthorne
    Oncology Conference Insight Blogs - ASH 2012: The combination of CHOP plus Rituxan (rituximab, Genentech/Roche; R-CHOP) has been the traditional standard of care in the United States and Europe for follicular lymphoma (FL) and mantle cell lymphoma (MCL). That regimen is associated with a range of adverse effects, including cardiac, hematologic, and neurologic toxicity, as well as infectious complications. Many physicians feel that CHOP has a role in treating more aggressive diseases such as diffuse large B-cell lymphoma, but debate as to whether such an aggressive regimen is warranted for treatment of patients with indolent lymphomas.
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  • Stephanie Hawthorne
    Oncology Conference Insight Blogs from ASH 2012: Acute meloid leukemia (AML) is a disease of high unmet need with a generally poor prognosis. This is especially true in the elderly population, with only approximately 45% of these patients receiving aggressive therapy with curative intent (Kantar Health, CancerMPact Treatment Architecture, 2012). Dacogen (decitabine, Eisai /Astex) was recently approved in Europe for use in elderly AML patients (but was rejected by the FDA in the same indication), and Phase III trials of both sapacitabine (Cyclacel) and Vidaza (azacytidine, Celgene) are ongoing in newly diagnosed elderly AML patients.
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